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GraphPad Software Inc
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Greiner Bio
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GraphPad Software Inc
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VILBER GmbH
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Image Search Results
Journal: Molecular therapy : the journal of the American Society of Gene Therapy
Article Title: HSP90-CDC37 functions as a chaperone for the oncogenic FGFR3-TACC3 fusion.
doi: 10.1016/j.ymthe.2022.02.009
Figure Lengend Snippet: Figure 6. Hsp90 inhibitor chemosensitizes F3-T3 glioma cells to TMZ (A) Combination drug matrix for estimates of interactions using CalcuSyn software. LN-229 cells stably expressing F3-T3 were treated (+/) onalespib and TMZ as shown and relative CCK8 viability was measured after 72 h. Percentages are the means from 3 independent experiments and indicate cell death relative to the untreated controls. (B) U-251 MG cells or LN-229 cells stably expressing F3-T3 treated with onalespib or 17-AAG in combination with DMSO or TMZ and assayed for colony formation after 8 days. Mean colonies (treatment/DMSO ±SD (n = 3); ***p < 0.001 each drug alone to each combination by 1-way ANOVA with Tukey’s post-test. (C) U-251 MG cells (legend continued on next page)
Article Snippet:
Techniques: Software, Stable Transfection, Expressing